Italics do not include punctuation marks (end marks or parentheses, for instance) next to the words being italicized unless those punctuation marks are meant to be considered as part of what is being italicized: "Have you read Stephen King's Pet Semetary ? (The question mark is not italicize here.) Also, do not italicize the apostrophe-s which creates the possessive of a title: "What is the Courant 's position on this issue?" You'll have to watch your word-processor on this, as most word-processors will try to italicize the entire word that you double-click on.
The Chicago Manual of Style takes a more complex approach to capitalizing hyphenated words. It agrees with Gregg that adverbs should be capitalized. Yet it recommends Run-in and Take-off because in and off are short and unstressed. It suggests Hand-me-downs for the same reason. Beyond that, Chicago does not capitalize the second part of a spelled-out hyphenated number ( Twenty-first and Two-thirds). I like its approach in a final rule: "Break a rule when it doesn't work." Well done, Chicago .