A carrier parent can have a chromosomally normal child, or a child who is a balanced carrier like the parent, or a DS child. Curiously, the chance that such a couple will have another DS child depends on which parent is the carrier. When the mother is a balanced carrier of a t(14;21), there is about a 12% risk for another DS child to be born in each subsequent pregnancy. When the father is the carrier, the observed risk drops to about 3% for DS. The reason for this difference in risks is not at all clear. A balanced translocation karyotype is shown in Figure 3.
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